The synthesis, the antitumor activity, the SAR and, whenever described, the possible mode of action of 1,2,4-triazine derivatives, their N-oxides, N,. N'-dioxides as well as the benzo- and hetero-fused systems are reported. Herein are treated derivatives disclosed to literature from the beginning of this century up to 2016. Among the three possible triazine isomers, 1,2,4-triazines are the most studied ones and many derivatives having remarkable antitumor activity have been reported in the literature and also patented reaching advanced phases of clinical trials.

Cascioferro, S., Parrino, B., Spano', V., Carbone, A., Montalbano, A., Barraja, P., et al. (2017). An overview on the recent developments of 1,2,4-triazine derivatives as anticancer compounds. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 142, 328-375 [10.1016/j.ejmech.2017.08.009].

An overview on the recent developments of 1,2,4-triazine derivatives as anticancer compounds

Cascioferro, Stella;Parrino, Barbara;Spanò, Virginia;Carbone, Anna;Montalbano, Alessandra;Barraja, Paola;Diana, Patrizia;Cirrincione, Girolamo
2017-12-15

Abstract

The synthesis, the antitumor activity, the SAR and, whenever described, the possible mode of action of 1,2,4-triazine derivatives, their N-oxides, N,. N'-dioxides as well as the benzo- and hetero-fused systems are reported. Herein are treated derivatives disclosed to literature from the beginning of this century up to 2016. Among the three possible triazine isomers, 1,2,4-triazines are the most studied ones and many derivatives having remarkable antitumor activity have been reported in the literature and also patented reaching advanced phases of clinical trials.
15-dic-2017
Settore CHIM/08 - Chimica Farmaceutica
Cascioferro, S., Parrino, B., Spano', V., Carbone, A., Montalbano, A., Barraja, P., et al. (2017). An overview on the recent developments of 1,2,4-triazine derivatives as anticancer compounds. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 142, 328-375 [10.1016/j.ejmech.2017.08.009].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/247793
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