Colorectal cancer (CRC) is one of the most common cancers worldwide. Various factors, including oxidative stress, where excessive productions of reactive oxygen species (ROS) and reactive nitrogen species (RNS) occur, contribute to its pathogenesis. Numerous studies have investigated the effect of antioxidant substances derived from food such fruits and vegetables; however, data on Lycopene are still rare. Stidies on HT-29 colorectal cancer cells and on animal models have shown that Lycopene has effects on cell proliferation and on the progression of the CRC by interacting with variuos cellular signaling pathways. this analysis of the literature focused on the antioxidant effect of Lycopene, a substance that is found in the tomato.

Carini, F., David, S., Tomasello, G., Mazzola, M., Damiani, P., Rappa, F., et al. (2017). COLORECTAL CANCER: AN UPDATE ON THE EFFECTS OF LYCOPENE ON TUMOR PROGRESSION AND CELL PROLIFERATION. JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS, 31(3), 774-796.

COLORECTAL CANCER: AN UPDATE ON THE EFFECTS OF LYCOPENE ON TUMOR PROGRESSION AND CELL PROLIFERATION

CARINI, Francesco;DAVID, Sabrina;TOMASELLO, Giovanni;RAPPA, Francesca;CAPPELLO, Francesco;LEONE, Angelo
2017-01-01

Abstract

Colorectal cancer (CRC) is one of the most common cancers worldwide. Various factors, including oxidative stress, where excessive productions of reactive oxygen species (ROS) and reactive nitrogen species (RNS) occur, contribute to its pathogenesis. Numerous studies have investigated the effect of antioxidant substances derived from food such fruits and vegetables; however, data on Lycopene are still rare. Stidies on HT-29 colorectal cancer cells and on animal models have shown that Lycopene has effects on cell proliferation and on the progression of the CRC by interacting with variuos cellular signaling pathways. this analysis of the literature focused on the antioxidant effect of Lycopene, a substance that is found in the tomato.
2017
Settore MED/18 - Chirurgia Generale
Settore MED/06 - Oncologia Medica
Settore BIO/11 - Biologia Molecolare
Carini, F., David, S., Tomasello, G., Mazzola, M., Damiani, P., Rappa, F., et al. (2017). COLORECTAL CANCER: AN UPDATE ON THE EFFECTS OF LYCOPENE ON TUMOR PROGRESSION AND CELL PROLIFERATION. JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS, 31(3), 774-796.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/243404
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