Contrasting data have been reported on the role of irisin, a novel myokine encoded by the FNDC5 gene, in NAFLD pathogenesis. We tested in patients with suspected NASH the association of FNDC5 variants, hepatic expression and circulating irisin with liver damage(F2-F4 fibrosis as main outcome). We also investigated whether irisin modulates hepatocellular fat accumulation and stellate cell activation in experimental models.
Petta, S., Valenti, L., Svegliati-Baroni, G., Ruscica, M., Pipitone, R., Dongiovanni, P., et al. (2017). Fibronectin type III domain-containing protein 5 rs3480 A>G polymorphism, irisin, and liver fibrosis in patients with Nonalcoholic fatty liver disease. THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM, 102(8), 2660-2669 [10.1210/jc.2017-00056].
Fibronectin type III domain-containing protein 5 rs3480 A>G polymorphism, irisin, and liver fibrosis in patients with Nonalcoholic fatty liver disease
PETTA, Salvatore;PIPITONE, Rosaria Maria;CAMMA', Calogero;DI MARCO, Vito;GRIMAUDO, Stefania;CABIBI, Daniela;CRAXI, Antonio
2017-01-01
Abstract
Contrasting data have been reported on the role of irisin, a novel myokine encoded by the FNDC5 gene, in NAFLD pathogenesis. We tested in patients with suspected NASH the association of FNDC5 variants, hepatic expression and circulating irisin with liver damage(F2-F4 fibrosis as main outcome). We also investigated whether irisin modulates hepatocellular fat accumulation and stellate cell activation in experimental models.
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