Radiation-engineered poly(N-vinyl pyrrolidone) nanogels are very interesting biocompatible nanocarriers for i.v. administration of therapeutics and contrast agents for bioimaging. The manufacturing process is fast and effective, it grants excellent control of particle size and simultaneous sterilization of the formed nanogels. Interestingly, primary amino groups and carboxyl groups, useful for (bio)conjugation, are also formed in a dose-dependent fashion. In this paper, by means of both numerical simulations and experiments, the origin of nanogel size control and functionalization is investigated. This understanding offers a new dimension for the design and production of radiation-sculptured multifunctional nanocarriers from aqueous solutions of polymers.

Dispenza, C., Sabatino, M., Grimaldi, N., Mangione, M., Walo, M., Murugan, E., et al. (2016). On the origin of functionalization in one-pot radiation synthesis of nanogels from aqueous polymer solutions. RSC ADVANCES, 6(4), 2582-2591 [10.1039/c5ra23926e].

On the origin of functionalization in one-pot radiation synthesis of nanogels from aqueous polymer solutions

DISPENZA, Clelia;SABATINO, Maria Antonietta;GRIMALDI, Natascia;
2016-01-01

Abstract

Radiation-engineered poly(N-vinyl pyrrolidone) nanogels are very interesting biocompatible nanocarriers for i.v. administration of therapeutics and contrast agents for bioimaging. The manufacturing process is fast and effective, it grants excellent control of particle size and simultaneous sterilization of the formed nanogels. Interestingly, primary amino groups and carboxyl groups, useful for (bio)conjugation, are also formed in a dose-dependent fashion. In this paper, by means of both numerical simulations and experiments, the origin of nanogel size control and functionalization is investigated. This understanding offers a new dimension for the design and production of radiation-sculptured multifunctional nanocarriers from aqueous solutions of polymers.
2016
Settore CHIM/07 - Fondamenti Chimici Delle Tecnologie
Dispenza, C., Sabatino, M., Grimaldi, N., Mangione, M., Walo, M., Murugan, E., et al. (2016). On the origin of functionalization in one-pot radiation synthesis of nanogels from aqueous polymer solutions. RSC ADVANCES, 6(4), 2582-2591 [10.1039/c5ra23926e].
File in questo prodotto:
File Dimensione Formato  
2016 Dispenza-et al RSC_Advances.pdf

accesso aperto

Dimensione 1.25 MB
Formato Adobe PDF
1.25 MB Adobe PDF Visualizza/Apri

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/165274
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 23
  • ???jsp.display-item.citation.isi??? 23
social impact