New terphenyl derivatives have been synthesized and tested for their effect on cell survival in serum-free cultures. These compounds protected HL60 cells from death and supported their growth with an activity higher than that of the natural 14-hydroxy-retro-retinol. Terphenyls 26 and 28 also possess antiapoptotic activity on neuronal cells, proving them as possible candidates for the treatment of neurodegenerative and ischemic diseases.
SIMONI D, GIANNINI G, ROBERTI M, RONDANIN R, BARUCHELLO R, ROSSI M, et al. (2005). Studies on the apoptotic activity of natural and synthetic retinoids: discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells. JOURNAL OF MEDICINAL CHEMISTRY, 48(13), 4293-4299 [10.1021/jm049080y].
Studies on the apoptotic activity of natural and synthetic retinoids: discovery of a new class of synthetic terphenyls that potently support cell growth and inhibit apoptosis in neuronal and HL-60 cells
Rossi, Matteo;INVIDIATA, Francesco;AIELLO, Stefania;GEBBIA, Nicolo';CROSTA, Lucia;GRIMAUDO, Stefania;ABBADESSA, Vincenzo;DI CRISTINA, Antonietta;
2005-01-01
Abstract
New terphenyl derivatives have been synthesized and tested for their effect on cell survival in serum-free cultures. These compounds protected HL60 cells from death and supported their growth with an activity higher than that of the natural 14-hydroxy-retro-retinol. Terphenyls 26 and 28 also possess antiapoptotic activity on neuronal cells, proving them as possible candidates for the treatment of neurodegenerative and ischemic diseases.
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