We isolated and characterized nanovesicles from edible Citrus limon with size and composition similar to mammalian-derived exosomes. Furthermore we show an in vitro and in vivo anti-proliferative and pro-apoptotic effect of these vesicles. This study opens to the possibility of using this natural plant-derived nanovesicles as antineoplastic agents.
Raimondo, S., Naselli, F., Fontana, S., Monteleone, F., Lo Dico, A., Saieva, L., et al. (2015). Isolation and characterization of Citrus limon L. derived nanovesicles: potential use as antineoplastic agent. In ISEV annual meeting 2015 [10.3402/jev.v4.27783].
Isolation and characterization of Citrus limon L. derived nanovesicles: potential use as antineoplastic agent
RAIMONDO, Stefania;NASELLI, Flores;FONTANA, Simona;Monteleone, Francesca;Lo Dico, Alessia;SAIEVA, Laura;ZITO, Giovanni;FLUGY PAPE', Anna Maria;MANNO, Mauro;DI BELLA, Maria Antonietta;DE LEO, Giacomo;ALESSANDRO, Riccardo
2015-01-01
Abstract
We isolated and characterized nanovesicles from edible Citrus limon with size and composition similar to mammalian-derived exosomes. Furthermore we show an in vitro and in vivo anti-proliferative and pro-apoptotic effect of these vesicles. This study opens to the possibility of using this natural plant-derived nanovesicles as antineoplastic agents.
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