Purpose: Oxidative stress plays a pivotal role in the pathogenesis of the metabolic syndrome and in the progression of its complications. Carbonylated proteins are a stable marker of severe oxidative stress because damage to the protein structure is irreversible and may cause an inhibition of their enzymatic activity or an increased susceptibility to proteolysis. ere are few data regarding protein oxidation in metabolic syndrome, although elevated levels of carbonyl groups are o en detected in subjects with obesity, diabetes mellitus, hypertension or dyslipidemia, well-known components of the metaboic syndrome. In particular, obesity, insulin resistance and diabetes mellitus are frequently associated with increased protein carbonylation. A relationship between insulin resistance, protein oxidative stress and in ammation has also been suggested as well as protein oxidation products are correlated with overexpression of resistin, TNF-α and IL-6. Conclusion: erapeutic interventions based on lifestyle modi cations and pharmacological agents in order to correct all the main risk factors in uence oxidative stress and protein carbonylation.

Hopps, E., Caimi, G. (2013). Protein oxidation in metabolic syndrome. CLINICAL AND INVESTIGATIVE MEDICINE-MEDECINE CLINIQUE ET EXPERIMENTALE, 36(1), E1-E8.

Protein oxidation in metabolic syndrome

HOPPS, Eugenia;CAIMI, Gregorio
2013-01-01

Abstract

Purpose: Oxidative stress plays a pivotal role in the pathogenesis of the metabolic syndrome and in the progression of its complications. Carbonylated proteins are a stable marker of severe oxidative stress because damage to the protein structure is irreversible and may cause an inhibition of their enzymatic activity or an increased susceptibility to proteolysis. ere are few data regarding protein oxidation in metabolic syndrome, although elevated levels of carbonyl groups are o en detected in subjects with obesity, diabetes mellitus, hypertension or dyslipidemia, well-known components of the metaboic syndrome. In particular, obesity, insulin resistance and diabetes mellitus are frequently associated with increased protein carbonylation. A relationship between insulin resistance, protein oxidative stress and in ammation has also been suggested as well as protein oxidation products are correlated with overexpression of resistin, TNF-α and IL-6. Conclusion: erapeutic interventions based on lifestyle modi cations and pharmacological agents in order to correct all the main risk factors in uence oxidative stress and protein carbonylation.
2013
Settore MED/09 - Medicina Interna
Hopps, E., Caimi, G. (2013). Protein oxidation in metabolic syndrome. CLINICAL AND INVESTIGATIVE MEDICINE-MEDECINE CLINIQUE ET EXPERIMENTALE, 36(1), E1-E8.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/104432
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