γδ T cells are capable of recognizing tumor cells and exert potent cellular cytotoxicity against a large range of tumors, including colon cancer. However, tumors utilize numerous strategies to escape recognition or killing by patrolling γδ T cells, such a downregulation of NKG2D ligands, MICA/B and ULBPs. Therefore, the combined upregulation of T-cell receptorand NKG2D ligands on tumor cells and induction of NKG2D expression on γδ T cells may greatly enhance tumor killing and unlock the functions of γδ T cells. Here, we briefly review current data on the mechanisms of γδ T-cell recognition and killing of colon cancer cells and propose that γδ T cells may represent a promising target for the design of novel and highly innovative immunotherapy in patients with colon cancer.

Ramutton, T., Buccheri, S., Dieli, F., Todaro, M., Stassi, G., Meraviglia, S. (2014). γδ T cells as a potential tool in colon cancer immunotherapy. IMMUNOTHERAPY, 6(9), 989-999 [10.2217/imt.14.59].

γδ T cells as a potential tool in colon cancer immunotherapy

RAMUTTON, Thiranut;BUCCHERI, Simona;DIELI, Francesco
;
TODARO, Matilde;STASSI, Giorgio;MERAVIGLIA, Serena
2014-01-01

Abstract

γδ T cells are capable of recognizing tumor cells and exert potent cellular cytotoxicity against a large range of tumors, including colon cancer. However, tumors utilize numerous strategies to escape recognition or killing by patrolling γδ T cells, such a downregulation of NKG2D ligands, MICA/B and ULBPs. Therefore, the combined upregulation of T-cell receptorand NKG2D ligands on tumor cells and induction of NKG2D expression on γδ T cells may greatly enhance tumor killing and unlock the functions of γδ T cells. Here, we briefly review current data on the mechanisms of γδ T-cell recognition and killing of colon cancer cells and propose that γδ T cells may represent a promising target for the design of novel and highly innovative immunotherapy in patients with colon cancer.
2014
Ramutton, T., Buccheri, S., Dieli, F., Todaro, M., Stassi, G., Meraviglia, S. (2014). γδ T cells as a potential tool in colon cancer immunotherapy. IMMUNOTHERAPY, 6(9), 989-999 [10.2217/imt.14.59].
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/103271
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