Some studies have shown that polymorphisms in the insulin growth factor-1 (IGF-1) signaling pathway genes could influence human longevity. However, the results of different studies are often inconsistent. Our aim was to investigate by systematic review and meta-analysis the association of the common polymorphisms defining the genetic variability of the IGF-1 signaling pathway associated with human longevity. Eleven studies investigating the association between the polymorphisms in the IGF-1 signaling pathway genes (IGF-1, IGF-1 receptor (IGF-1R), Forkhead box O3A (FOXO3A) and Silent mating type information regulation 1 (SIRT1)) and longevity were found and analyzed. The model-free approach was applied to meta-analyze these studies. No association was reported between the single nucleotide polymorphisms (SNPs) of IGF-1 and longevity in the available study. The meta-analysis of available data from four studies, showed a significant association with the IGF-1R polymorphism rs2229765, suggesting that subjects with the A-bearing genotype have greater chance of longevity. Concerning the five studies on FOXO3A SNPs, for the rs2764264 significant association with longevity was observed for C allele when only males were included in the analysis. Statistically significant results were obtained for other SNPs as well, i.e. rs2802292 ( G allele), rs9400239 and rs479744 (T and A alleles, respectively). For rs9400239 the association was observed in male long lived with a lower odds ratio than in centenarians while in rs479744 it was highlighted a significant association in centenarians. Concerning SIRT1, no association between the SNPs under study and longevity was observed in the only available report. Current findings suggest that both IGF-1R and FOXO3A polymorphisms could be associated with longevity. The high degree of between-study heterogeneity and the low number of available studies underline the need for further methodologically adequate analyses to confirm these evidences.

Di Bona, D., Accardi, G., Virruso, C., Candore, G., Caruso, C. (2014). Association Between Genetic Variations In The Insulin/Insulin-Like Growth Factor (Igf-1) Signaling Pathway And Longevity: A Systematic Review And Meta-Analysis. CURRENT VASCULAR PHARMACOLOGY, 12, 674-681.

Association Between Genetic Variations In The Insulin/Insulin-Like Growth Factor (Igf-1) Signaling Pathway And Longevity: A Systematic Review And Meta-Analysis.

ACCARDI, Giulia;VIRRUSO, Claudia;CANDORE, Giuseppina;CARUSO, Calogero
2014-01-01

Abstract

Some studies have shown that polymorphisms in the insulin growth factor-1 (IGF-1) signaling pathway genes could influence human longevity. However, the results of different studies are often inconsistent. Our aim was to investigate by systematic review and meta-analysis the association of the common polymorphisms defining the genetic variability of the IGF-1 signaling pathway associated with human longevity. Eleven studies investigating the association between the polymorphisms in the IGF-1 signaling pathway genes (IGF-1, IGF-1 receptor (IGF-1R), Forkhead box O3A (FOXO3A) and Silent mating type information regulation 1 (SIRT1)) and longevity were found and analyzed. The model-free approach was applied to meta-analyze these studies. No association was reported between the single nucleotide polymorphisms (SNPs) of IGF-1 and longevity in the available study. The meta-analysis of available data from four studies, showed a significant association with the IGF-1R polymorphism rs2229765, suggesting that subjects with the A-bearing genotype have greater chance of longevity. Concerning the five studies on FOXO3A SNPs, for the rs2764264 significant association with longevity was observed for C allele when only males were included in the analysis. Statistically significant results were obtained for other SNPs as well, i.e. rs2802292 ( G allele), rs9400239 and rs479744 (T and A alleles, respectively). For rs9400239 the association was observed in male long lived with a lower odds ratio than in centenarians while in rs479744 it was highlighted a significant association in centenarians. Concerning SIRT1, no association between the SNPs under study and longevity was observed in the only available report. Current findings suggest that both IGF-1R and FOXO3A polymorphisms could be associated with longevity. The high degree of between-study heterogeneity and the low number of available studies underline the need for further methodologically adequate analyses to confirm these evidences.
2014
Settore MED/04 - Patologia Generale
Di Bona, D., Accardi, G., Virruso, C., Candore, G., Caruso, C. (2014). Association Between Genetic Variations In The Insulin/Insulin-Like Growth Factor (Igf-1) Signaling Pathway And Longevity: A Systematic Review And Meta-Analysis. CURRENT VASCULAR PHARMACOLOGY, 12, 674-681.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/10447/100647
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